Joingenome Diagnostics (Joingenome Dx), as a clinical medical laboratories sponsored by Joinstar Biotechnology and high-portfolio scientists, provides a comprehensive array of clinical molecular testing services for patients with inherited/rare diseases as well as cancers.
CMA is a molecular cytogenetic method for analyzing copy number variations. JunoArrayTM ‘s genome-wide array based solutions enable detection of known and novel structural aberrations such as copy number variations (CNVs), chromosomal imbalances, regions exhibiting loss/absence of heterozygosity (LOH), uniparental isodisomy (UDP) and even low-level mosaicism.
Key features of JunoArrayTM
▶Combines copy number markers with SNP markers at medium to high density to provide the highest resolution and broadest coverage
▶Reliably detects copy number changes across the genome with a resolution down to 25kb
▶Confidently detects the presence of mosaicism down to 20%
▶Compatible with a wide range of samples including blood, DNA, fresh and frozen tissues, amniocytes, bone marrow aspirate and even formalin fixed paraffin embedded (FFPE) samples
▶An impressive TAT of 15 business days
▶If an aberration is detected, we automatically validate this in the index using a second method (MLPA or qPCR) without additional costs.
▶As a first-tier testing for cases of mental retardation and/or multiple malformations given that a considerable number of chromosomal rearrangements and CNVs have been implicated in such disorders
▶In conjunction with whole exome sequencing to complement SNV with CNV detection. JunoArrayTM can be ordered either as a step-wise analysis with WES or as part of an attractive combined WES package
▶CNV screening for large NGS panels if sequencing results are negative and single exon resolution analysis is not available
▶For deletion/duplication analysis of extremely large genes where gross deletions involving large segment of gene, flanking intergenic regions or neighboring genes are frequently reported
▶To diagnose uniparental iso-disomy
▶For detection of mosaicism
▶This analysis can be done as a prenatal testing. In this case, trio analysis of the index and the parents is highly recommended.
For certain patients the combination of symptoms does not allow the clinician to pinpoint a potential diagnosis. In such cases ordering genetic testing becomes complex and a stepwise diagnostic strategy often substantially increases costs. Furthermore, a delayed diagnosis may have a significant impact on the patient’s quality of life.
Most of the disease-causing mutations that have been identified so far (about 85%) are located within the coding regions of the genome. Whereas most genetic tests focus on a single gene or on a subset of predetermined genes, whole exome sequencing (WES) test examines all of the coding genes, especially those genes with known diseases or phenotypes correlation simultaneously.
JunoXomeTM, Joingenome®’s whole exome sequencing service, offers a fast and cost-effective one-step solution which involves sequencing all exons across the genome.
Indications for WES
For several patients the combination of symptoms does not allow suspecting specific single genetic causes with a high certainty. Therefore medical answers are likely to be obtained only through sequencing the complete coding region, i.e. the whole exome.
High-quality reporting is a key essential for meaningful application of genomic testing in clinical setting. Our philosophy is more than just producing technical data. The extensive interpretation of clinical data delivered with our comprehensive medical reports includes differential diagnostic approaches as well as a detailed interpretation of key findings.
▶Clinical information evaluation
▶Detailed method description
▶Clear results of identified variants following international best-practice guidelines (American College of Medical Genetics)
▶Comprehensive medical interpretation with differential diagnostic approaches, if applicable
▶References to publications supporting the medical and scientific results
▶Recommendations for follow-up analyses for specific diseases
▶Coverage report of WES
Hangzhou Medical Intelligent Express Co.,Ltd is a platfo is a platform service provider which focus on medical and biological medicine industry supply chain optimization and service integration. Medical Intelligent Express is located in Joinstar Biomedical Valley (Hangzhou) in Yuhang Economic and Technology Development Zone, which Is the only biological high-tech zone in Zhejiang province, with 6000 square meters room temperature storage room with GSP standard and 5000 cubic meters cold room. We adhere to the business philosophy of "user as the center, target oriented", and are committed to provide integrated supply chain solutions for the field of medical apparatus instruments, life science and biological medicine
With more overseas collaborations in biological medicine industry, with unmet need of logistics process for biological medicine special goods Entry-Exit under existing mode , we put forward the idea of the Green Channel for setup integration industry. In 2016, We passed Customs inspection and received ‘the Public Bonded Warehouse Registration Certificate’, and passed inspection by Zhejiang Entry-Exit Inspection and Quarantine Bureau and established ‘ Zhejiang Public Service Platform for Biological Medicine Special Goods Entry-Exit ’ in 2017. Under this model, it will greatly enhance efficiency of all kinds of examination and approval, improve efficiency of the inspection and Customs clearance, save the cost of products importation.
Through the model of process optimization and service improvement for medical supply chain, Medical Intelligent Express assists numerous biomedical research teams, product supply end and market circulation end to optimize the process, reduce the operation cost and improve the comprehensive competitiveness.
Zhejiang Cross-Border Services center for Biomedical products undertakes three functions , centralized supervision and inspection for special goods, Customs shared bonded warehouse, and service for industry, including acting import and export licensing examination and approval, foreign trade clearance, cold chain storage and transportation, bonded logistics, and supply chain finance etc. Under the condition of controllable risks, We innovate and provide services for biomedical and medical industries,being the only public service platform in China that integrates entry-exit inspection and quarantine, Customs shared bonded warehouse and cold chain supply chain.
Medical Intelligent Express devoted ourselves to professional cold chain logistics ,centralized storage for medical equipment, life science, biological medicine, warehouse was built as per GSP standard with 6000 square meters of storage and 5000 cubic meters of Cold Room, which shall meet needs of storage, professional cold chain transportation for medical equipment manufactures and distributors. Professional logistics system covers the main medical institutions within Zhejiang province, realize close connection among the entrusted enterprise, Medical Intelligent Express and end users. Through centralized third-party storage and transportation; Simplify supply chain storage, logistics and management costs, eliminate unnecessary waste and improve supply chain competitiveness.
With incubator, various temperature monitoring recorder, information system and other methods, effectively control cold chain, anti-loss, anti-replacement, traceability and other key requirement for vaccines, various biological specimens, blood samples and other important products during the delivery process
Setup cloud-based real-time monitoring service platform, independently develop warehouse, car, warehouse , freezer, vehicle mounted ,incubator temperature and humidity recorder based on GPRS wireless sensor network technology. Focus on every step during the circulation and storage of cold chain logistics with computer, APP , Weichat to real-time monitor temperature, humidity and geographic information, to know information real-time changes by software and hardware during the process of cold chain. As such, the overall solutions for medical cold chain logistics are really realized.
Joinstar Innovation Works is a professional technology incubator which focus on medical IVD products, Precision Medicine and biological information segment. Joinstar Innovation Works hold fast to the incubation concept of " R&D begins from a place nearby market, Distribution Model setup from a place nearby technology frontier ", relying on JOINSTAR advantage which is covering whole industrial chain in medical IVD field, so as to provide the most direct and effective guide and help for research team from the laboratory samples to products and then commercial products; Provide leading technology products and incubation investment projects for distributors teams who iterate or create new business models.
Joinstar Innovation Works has formed a complete industrial upstream and downstream incubation collaborative chain by integrating the supply and demand resources between different enterprises in the industrial chain, which helps enterprises which located at Innovation works to quickly get through medical field. It has formed the industrial ecological circle of " One Network,Two Platform; Three Centers". Joinstar Innovation Works was recognized as a "Provincial Incubator for Science and Technology business " in 2016. It was recognized as a Provincial "Small and Micro Enterprise Entrepreneurship and Innovation Demo Park" In 2017. In addition, it was successively awarded as "Top 10 Scientific and Technological Innovation Parks in yuhang " in 2016, and "Best Incubation Park Award" which is 2017 first Industrial Development Role Model Award in Yuhang Economic and Technology Development Zone, and 2018" Entrepreneurship and Innovation Service Role Model Award " in Yuhang Economic and Technology Development Zone. A number of incubation projects were awarded as the national level innovation industry awards.
Joinstar Innovation Works has has formed a research team of key core technologies, which is a leading team and holds our own IPs for biology materials development and nano-microparticles preparation with several years of industrial incubation, such as Joinstar Institutes for Liquid Phase Chips, Kunteng Nano , Hangzhou Biogenome Biotech. Formed reagent and equipment industrial chain for POCT, molecular diagnosis and clinical chemistry & Immunoassay represented by Xianyi Technology and Desinpro; Intelligent medical projects, such as gene diagnosis, artificial intelligence and biological information analysis represented by Canhelp Genomics and Joingenome; Multi-level and comprehensive innovation technology reserve, such as digital instant testing project for primary medical care.
Joinstar Innovation Works rely on JOINSTAR R&D center, gradually formed Boyin antibody development platform, Joinstar Institutes for Liquid Phase Chips, Joingenome bioinformatics analysis platform, Desinpro equipment research and development and manufacturing platform, and in the service of biological medicine industry, Zhejiang province, Zhejiang Exit & Entry centralized supervision platform for biological products , Customs bonded warehouse, and Medical Intelligent Express third-party storage platform for medical equipment. Joinstar Innovation Works is committed to becoming a leading incubator platform in the biomedical incubation field within the Yangtze river delta.