l Assessment of glomerular filtration function
The main reason for the increase of β2-MG in blood and the normal β2-MG in urine may be the decrease of glomerular filtration function, which is commonly in acute and chronic nephritis and renal failure, etc.
l Assessment of renal tubular reabsorption
The level of β2-MG in blood is normal but increases in urine is mainly due to the obviously impaired renal tubular reabsorption, which is found in congenital proximal renal tubules function defect, Fanconi syndrome, chronic cadmium poisoning, Wilson's disease, renal transplant rejection, etc.
l Other diseases
Elevated levels of β2-MG may also be seen in cancers involving white blood cells, but it is particularly meaningful in people newly diagnosed with multiple myeloma.