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Lipoprotein-associated phospholipase A2 Detection Kit (Fluorescence Dry Quantitative Immunoassay) Download the picture album

【 Characteristics 】

Sample type: Serum, EDTA anticoagulated whole blood or plasma

Sample absorption: 120 μL

Linear range: 5.0-800.0 ng/mL

Incubation time: 18 minutes

Reference value: < 175 ng/mL

Packing specifications: 20T / box, 25T / box, 60T / box, 100T / box.

Clinical application


Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a blood vessel-specific marker of inflammation. Studies have found that Lp-PLA2 is an independent risk factor for coronary heart disease and ischemic stroke. Lp-PLA2 is one of the subtypes in the phospholipase superfamily, also known as platelet activating factor acetylhydrolase, and is secreted by macrophages, T cells, and mast cells in the lining of blood vessels. Lp-PLA2 expression was increased in atherosclerotic plaques, and was strongly expressed in macrophages of vulnerable plaque fiber caps. Lp-PLA2 hydrolyzes oxidized phospholipids in oxidized low-density lipoprotein (ox-LDL) to produce lipid pro-inflammatory substances, such as lysolecithin and oxidized free fatty acids, which in turn produces a variety of atherogenic effects, including endothelial cells Apoptosis and endothelial dysfunction, stimulate the production of adhesion factors and cytokines. These substances can further generate a self-reinforcing cycle through chemotactic inflammatory cells, generating more pro-inflammatory substances. Lp-PLA2 is of great significance in the prediction, treatment and prognosis of cardiovascular and cerebrovascular embolism diseases.

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